Integra Resources (ITRG) has had the highest return this decade by a US stock, returning 691,566.7%.

ASSET	DECADE	% RETURN
Integra Resources (ITRG)	2020s	691,566.67%
Applied Digital (APLD)	2020s	519,344.44%
MDxHealth SA ADR (MDXH)	2020s	348,990.91%
DevvStream Corp Common Stock (DEVS)	2020s	110,900%
BioNexus Gene Lab Corp Common stock (BGLC)	2020s	88,607.32%
COSCIENS Biopharma (CSCI)	2020s	49,730.51%
Castellum (CTM)	2020s	18,445.45%
Heart Test Laboratories Inc Common Stock (HSCS)	2020s	9,311.76%
Regencell Bioscience (RGC)	2020s	8,585.88%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2020s	6,304.83%
Azitra (AZTR)	2020s	5,757.14%
Innodata (INOD)	2020s	5,298.25%
Centrus Energy (LEU)	2020s	4,711.48%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	2020s	4,549.86%
DeFi Technologies (DEFT)	2020s	4,437.82%
Galaxy Digital (GLXY)	2020s	4,131.1%
QMMM Holdings Limited Ordinary Shares (QMMM)	2020s	3,880%
Cybin (CYBN)	2020s	3,848.98%
Celestica (CLS)	2020s	3,673.77%
IsoEnergy (ISOU)	2020s	3,501.99%
Celsius (CELH)	2020s	3,278.26%
NVIDIA (NVDA)	2020s	3,034.02%
Santech (STEC)	2020s	2,934.67%
Guardforce AI (GFAI)	2020s	2,741.35%
Alpha Metallurgical Resources (AMR)	2020s	2,715.52%