Zivo Bioscience (ZIVO) had the highest return between 2000 and 2003 by a US stock, returning 139,636,263.6%.

ASSET	YEARS	% RETURN
Zivo Bioscience (ZIVO)	2000-2003	139,636,263.64%
Live Ventures (LIVE)	2000-2003	8,207,635.94%
Hirequest (HQI)	2000-2003	5,763,450%
Eldorado Gold (EGO)	2000-2003	5,113,366.67%
Viewbix Inc Common Stock (VBIX)	2000-2003	722,526.91%
ImmunoPrecise Antibodies (HYFT)	2000-2003	122,042.86%
Inseego (INSG)	2000-2003	99,733.33%
AlphaTON Capital (ATON)	2000-2003	38,013.21%
DeFi Technologies (DEFT)	2000-2003	32,900%
Interlink Electronics (LINK)	2000-2003	10,752.17%
Americas Silver (USAS)	2000-2003	8,347.37%
Flexible Solutions International (FSI)	2000-2003	4,032.97%
MEDIFAST (MED)	2000-2003	4,000.5%
China Yuchai International (CYD)	2000-2003	3,505.67%
Xcel Brands (XELB)	2000-2003	3,400%
Odyssey Marine Exploration (OMEX)	2000-2003	1,900%
American Vanguard (AVD)	2000-2003	1,526.47%
Yunhong Green CTI (YHGJ)	2000-2003	1,375.92%
Hovnanian Enterprises (HOV)	2000-2003	1,279.17%
CarMax (KMX)	2000-2003	1,274.67%
John B Sanfilippo & Son (JBSS)	2000-2003	1,176.02%
USANA Health Sciences (USNA)	2000-2003	1,159.47%
BJs Restaurants (BJRI)	2000-2003	1,156.47%
Meritage (MTH)	2000-2003	1,133.71%
SunOpta (STKL)	2000-2003	1,036%