Zivo Bioscience (ZIVO) had the highest return between 2000 and 2004 by a US stock, returning 23,999,900%.

ASSET	YEARS	% RETURN
Zivo Bioscience (ZIVO)	2000-2004	23,999,900%
Eldorado Gold (EGO)	2000-2004	4,699,200%
Hirequest (HQI)	2000-2004	4,077,900%
Live Ventures (LIVE)	2000-2004	3,844,471.88%
Viewbix Inc Common Stock (VBIX)	2000-2004	722,526.91%
Inseego (INSG)	2000-2004	323,400%
NextTrip (NTRP)	2000-2004	191,900%
DeFi Technologies (DEFT)	2000-2004	87,900%
ImmunoPrecise Antibodies (HYFT)	2000-2004	85,614.29%
AlphaTON Capital (ATON)	2000-2004	64,050.94%
Xcel Brands (XELB)	2000-2004	28,400%
Interlink Electronics (LINK)	2000-2004	14,477.74%
Oramed Pharmaceuticals (ORMP)	2000-2004	8,275.76%
First Majestic Silver (AG)	2000-2004	7,263.56%
Americas Silver (USAS)	2000-2004	7,005.26%
Frontline (FRO)	2000-2004	6,122.23%
Flexible Solutions International (FSI)	2000-2004	3,266.33%
American Vanguard (AVD)	2000-2004	2,306.11%
Oragenics (OGEN)	2000-2004	2,267.42%
Versus Systems Inc. (VS)	2000-2004	2,200%
Meritage (MTH)	2000-2004	1,996.69%
Cheniere Energy (LNG)	2000-2004	1,795.86%
Deckers Outdoor (DECK)	2000-2004	1,690.53%
NVR (NVR)	2000-2004	1,511.31%
China Yuchai International (CYD)	2000-2004	1,508.22%