Monster Beverage (MNST) had the highest return between 2000 and 2012 by a US stock in the S&P 500 (GSPC), returning 19,646%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2000-2012	19,645.96%
Deckers Outdoor (DECK)	2000-2012	4,503.36%
Tractor Supply (TSCO)	2000-2012	4,402.13%
Intuitive Surgical (ISRG)	2000-2012	2,624.41%
DaVita HealthCare Partners (DVA)	2000-2012	2,356.22%
Old Dominion Freight Line (ODFL)	2000-2012	2,321.47%
Tapestry (TPR)	2000-2012	2,238.27%
Gilead Sciences (GILD)	2000-2012	1,957.31%
Apple (AAPL)	2000-2012	1,947.83%
Contura Energy (CTRA)	2000-2012	1,865.17%
NVR (NVR)	2000-2012	1,826.7%
JB Hunt Transport Services (JBHT)	2000-2012	1,776.19%
Johnson Controls International (JCI)	2000-2012	1,728.92%
Cognizant Technology Solutions Corp Class A (CTSH)	2000-2012	1,508.33%
Axon Enterprise (AXON)	2000-2012	1,432.66%
EOG Resources (EOG)	2000-2012	1,400.4%
Ametek (AME)	2000-2012	1,382.82%
BlackRock (BLK)	2000-2012	1,338.89%
Hologic (HOLX)	2000-2012	1,276.97%
Ross Stores (ROST)	2000-2012	1,242.78%
CoreSite Realty (COR)	2000-2012	1,225.88%
Regeneron Pharmaceuticals (REGN)	2000-2012	1,197.21%
CF Industries (CF)	2000-2012	1,196.64%
Wynn Resorts (WYNN)	2000-2012	1,178.67%
Mastercard (MA)	2000-2012	1,142.51%