Booking (BKNG) had the highest return between 1999 and 2003 by a US stock in the S&P 500 (GSPC), returning 5,870,500%.

ASSET	YEARS	% RETURN
Booking (BKNG)	1999-2003	5,870,500%
Axon Enterprise (AXON)	1999-2003	1,076.79%
Laboratory Corporation of America (LH)	1999-2003	975.01%
NVR (NVR)	1999-2003	877.2%
Deckers Outdoor (DECK)	1999-2003	864.35%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2003	794.24%
Qualcomm (QCOM)	1999-2003	728.02%
Quest Diagnostics (DGX)	1999-2003	723.78%
Tapestry (TPR)	1999-2003	655.01%
Pool (POOL)	1999-2003	629.21%
Genesis Healthcare (GEN)	1999-2003	541.9%
Tractor Supply (TSCO)	1999-2003	536.57%
Gilead Sciences (GILD)	1999-2003	468.62%
Lam Research (LRCX)	1999-2003	434.56%
UnitedHealth (UNH)	1999-2003	433.21%
Trimble (TRMB)	1999-2003	409.29%
Biogen (BIIB)	1999-2003	367.89%
Lennar (LEN)	1999-2003	364.93%
Cooper Companies (COO)	1999-2003	356.32%
Old Dominion Freight Line (ODFL)	1999-2003	344.56%
NVIDIA (NVDA)	1999-2003	341.9%
Amphenol (APH)	1999-2003	324.38%
Freeport-McMoran Copper & Gold (FCX)	1999-2003	300.89%
Brown & Brown (BRO)	1999-2003	290.4%
BlackRock (BLK)	1999-2003	282.5%