Nutex Health (NUTX) had the highest return in April 2022 by a small-cap US stock, returning 129.8%.

ASSET	MONTH	% RETURN
Nutex Health (NUTX)	April 2022	129.76%
Dingdong (Cayman) Limited ADR (DDL)	April 2022	41.22%
Ardmore Shpng (ASC)	April 2022	38.44%
Tsakos Energy Navigation (TEN)	April 2022	36.47%
Oruka Therapeutics (ORKA)	April 2022	33.15%
Highpeak Energy Acquisition (HPK)	April 2022	22.84%
Hallador Energy (HNRG)	April 2022	22.41%
Esperion Therapeutics (ESPR)	April 2022	19.83%
Nordic American Tankers (NAT)	April 2022	19.63%
LSI Industries (LYTS)	April 2022	18.84%
Cango (CANG)	April 2022	18.73%
NACCO Industries (NC)	April 2022	18.15%
Universal Technical Institute (UTI)	April 2022	17.73%
SandRidge Energy (SD)	April 2022	17.46%
Clearwater Paper (CLW)	April 2022	17.41%
Trevi Therapeutics (TRVI)	April 2022	17.39%
Lightwave Logic (LWLG)	April 2022	17.22%
Greene County Bancorp (GCBC)	April 2022	16.7%
Teekay Tankers (TNK)	April 2022	15.85%
EZCORP (EZPW)	April 2022	15.51%
Talos Energy (TALO)	April 2022	15.37%
Sprinklr (CXM)	April 2022	14.51%
WideOpenWest (WOW)	April 2022	14.44%
Summit Midstream (SMC)	April 2022	13.98%
Envela (ELA)	April 2022	13.6%

Small-cap stocks are treated as having a market cap between $300M and $2B.