Brera Holdings PLC Class B Ordinary Shares (BREA) has had the highest return since 2021 by a US stock, returning 1,328,900%.

ASSET	% RETURN
Brera Holdings PLC Class B Ordinary Shares (BREA)	1,328,900%
NioCorp Developments Ltd Common Stock (NB)	724,900%
MDxHealth SA ADR (MDXH)	258,990.91%
BioNexus Gene Lab Corp Common stock (BGLC)	232,073.91%
CID HoldCo, Inc Warrants (DAICW)	44,650%
Wearable Devices (WLDSW)	7,809.6%
Applied Digital (APLD)	6,162.22%
Regencell Bioscience (RGC)	4,054.53%
USA Rare Earth (USARW)	3,564.71%
Webull Corporation Warrants (BULLW)	3,383.33%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	3,301.92%
Azitra (AZTR)	2,757.14%
Power Solutions International, Inc Common Stock (PSIX)	2,552.32%
HCM II Acquisition (HONDW)	2,376.19%
Sezzle Inc Common Stock (SEZL)	2,333.64%
Celestica (CLS)	2,298.53%
Blue Gold Limited Warrant (BGLWW)	2,250%
Triumph (TGI)	2,206.72%
TSS, Inc Common Stock (TSSI)	2,126.21%
Zivo Bioscience (ZIVO)	1,901.1%
Cohen Circle Acquisition Corp I Warrant (CCIRW)	1,852.63%
Trump Media & Technology (DJTWW)	1,701.49%
Euroseas (ESEA)	1,648.92%
Cresud SACIF y A Warrant (CRESW)	1,620%
Critical Metals Corp Warrants (CRMLW)	1,533.33%