MDxHealth SA ADR (MDXH) has had the highest return since 2021 by a US stock, returning 348,990.9%.

ASSET	% RETURN
MDxHealth SA ADR (MDXH)	348,990.91%
BioNexus Gene Lab Corp Common stock (BGLC)	158,030.43%
DevvStream Corp Common Stock (DEVS)	110,900%
Applied Digital (APLD)	99,633.33%
Castellum (CTM)	23,081.82%
Heart Test Laboratories Inc Common Stock (HSCS)	9,311.76%
Regencell Bioscience (RGC)	8,585.88%
Azitra (AZTR)	5,757.14%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	4,549.86%
QMMM Holdings Limited Ordinary Shares (QMMM)	3,880%
Celestica (CLS)	3,747.85%
Santech (STEC)	2,934.67%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2,808.09%
Guardforce AI (GFAI)	2,741.35%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2,668.33%
Power Solutions International, Inc Common Stock (PSIX)	2,252.94%
Alpha Metallurgical Resources (AMR)	2,135.07%
Comfort Systems USA (FIX)	2,074.01%
Lottery (SEGG)	2,015.7%
Build-A-Bear Workshop (BBW)	1,806.38%
Vista Oil Gas ADR (VIST)	1,793.44%
Sterling Construction (STRL)	1,778.8%
Sezzle (SEZL)	1,714.57%
TSS, Inc Common Stock (TSSI)	1,562.07%
FTAI Aviation (FTAI)	1,531.05%