Fulcrum Therapeutics (FULC) had the highest return in August 2021 by a small-cap US stock, returning 303.5%.

ASSET	MONTH	% RETURN
Fulcrum Therapeutics (FULC)	August 2021	303.53%
DeFi Technologies (DEFT)	August 2021	128.6%
Dynavax Technologies (DVAX)	August 2021	108.35%
Taskus (TASK)	August 2021	103.76%
Skywater Technology (SKYT)	August 2021	91.51%
Valneva SE ADR (VALN)	August 2021	85.31%
Altimmune (ALT)	August 2021	63.83%
Invivyd (IVVD)	August 2021	61.14%
Empresa Distribuidora y Comercializadora Norte SA ADR (EDN)	August 2021	59.82%
Palvella Therapeutics (PVLA)	August 2021	55.33%
Ryerson (RYI)	August 2021	47.59%
Atlanticus (ATLC)	August 2021	46.74%
SandRidge Energy (SD)	August 2021	46.38%
Vir Biotechnology (VIR)	August 2021	44.13%
Monte Rosa Therapeutics (GLUE)	August 2021	43.05%
Sana Biotechnology (SANA)	August 2021	42.97%
Youdao (DAO)	August 2021	42.45%
Bit Digital (BTBT)	August 2021	41.5%
Array Technologies (ARRY)	August 2021	40.22%
Aquestive Therapeutics (AQST)	August 2021	39.63%
ADC Therapeutics (ADCT)	August 2021	38.9%
Immuneering (IMRX)	August 2021	38.64%
Baldwin Insurance (BWIN)	August 2021	37.81%
Lightwave Logic (LWLG)	August 2021	37.54%
Flywire (FLYW)	August 2021	37.09%

Small-cap stocks are treated as having a market cap between $300M and $2B.