Regencell Bioscience (RGC) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 9,241.3%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	9,241.32%
QMMM Holdings Limited Ordinary Shares (QMMM)	2025	9,155.81%
Diginex Limited Ordinary Shares (DGNX)	2025	2,176.06%
Abivax SA American Depositary Shares (ABVX)	2025	1,545.3%
Oncology Institute (TOI)	2025	922.88%
FiEE (FIEE)	2025	904.59%
DeFi Development (DFDV)	2025	845.91%
Newegg Commerce (NEGG)	2025	784.13%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	727.5%
Relmada Therapeutics (RLMD)	2025	723.05%
Palvella Therapeutics (PVLA)	2025	710.42%
Cidara Therapeutics (CDTX)	2025	709.11%
Abits (ABTS)	2025	707.21%
Celcuity LLC (CELC)	2025	637.52%
Nanobiotix (NBTX)	2025	572.99%
Charming Medical Limited Class A Ordinary Shares (MCTA)	2025	539.54%
Sandisk (SNDK)	2025	471.22%
Lizhi (SOGP)	2025	460.55%
Inhibrx Biosciences (INBX)	2025	448.2%
Invivyd (IVVD)	2025	431.91%
GRAIL, LLC (GRAL)	2025	424.97%
Global Interactive Technologies (GITS)	2025	414.52%
JFB Construction Holdings Class A Common Stock (JFB)	2025	395.29%
ThredUp (TDUP)	2025	388.89%
Dominari (DOMH)	2025	383.85%