Brera Holdings PLC Class B Ordinary Shares (BREA) had the highest return between 2021 and 2024 by a US stock, returning 1,645,900%.

ASSET	YEARS	% RETURN
Brera Holdings PLC Class B Ordinary Shares (BREA)	2021-2024	1,645,900%
DevvStream Corp Common Stock (DEVS)	2021-2024	751,900%
Diversified Energy (DEC)	2021-2024	427,418.92%
MDxHealth SA ADR (MDXH)	2021-2024	215,354.55%
BioNexus Gene Lab Corp Common stock (BGLC)	2021-2024	121,639.13%
Azitra (AZTR)	2021-2024	50,614.29%
Castellum (CTM)	2021-2024	45,354.55%
Applied Digital (APLD)	2021-2024	20,273.33%
Heart Test Laboratories Inc Common Stock (HSCS)	2021-2024	11,135.29%
Next Technology (NXTT)	2021-2024	8,409.15%
Lottery (SEGG)	2021-2024	7,900%
Guardforce AI (GFAI)	2021-2024	6,775%
Zivo Bioscience (ZIVO)	2021-2024	2,257.46%
Vista Oil Gas ADR (VIST)	2021-2024	1,989.19%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2021-2024	1,793%
Alpha Metallurgical Resources (AMR)	2021-2024	1,757.33%
TSS, Inc Common Stock (TSSI)	2021-2024	1,535.86%
Kolibri Global Energy Inc Common stock (KGEI)	2021-2024	1,230%
Build-A-Bear Workshop (BBW)	2021-2024	1,121.59%
Weatherford International (WFRD)	2021-2024	1,113.42%
Energy Services Of America (ESOA)	2021-2024	1,091.81%
Tecnoglass (TGLS)	2021-2024	1,086.55%
Celestica (CLS)	2021-2024	1,032.52%
Sezzle (SEZL)	2021-2024	1,029.36%
RCM Technologies (RCMT)	2021-2024	991.63%