ReShape Lifesciences (RSLS) has had the highest return this year by a US stock, returning 92,400%.

ASSET	YEAR	% RETURN
ReShape Lifesciences (RSLS)	2025	92,400%
Regencell Bioscience (RGC)	2025	7,104.92%
Mobile Global Esports (MGAM)	2025	1,775%
Asset Entities Inc Class B Common Stock (ASST)	2025	1,524%
Janover Inc Common Stock (JNVR)	2025	1,491.72%
Diginex Limited Ordinary Shares (DGNX)	2025	1,440.61%
Abits (ABTS)	2025	1,218.18%
Splash Beverage Group, Inc WT (SBEV.WT)	2025	837.5%
Oncology Institute (TOI)	2025	815.03%
Webull Corporation Warrants (BULLW)	2025	804.09%
HCM II Acquisition (HONDW)	2025	749.14%
Oncology Institute (TOIIW)	2025	682.14%
Top KingWin (WAI)	2025	543.27%
Aimfinity Investment Corp I Warrant (AIMAW)	2025	542.86%
Dominari (DOMH)	2025	536.08%
Global Interactive Technologies (GITS)	2025	526.56%
Oriental Culture Holding (OCG)	2025	505.04%
Protagenic Therapeutics (PTIX)	2025	487.9%
Marblegate Acquisition Corp Warrant (GATEW)	2025	466.67%
TMC the metals company Inc Warrants (TMCWW)	2025	456.6%
Arena (AREN)	2025	415.22%
Regulus Therapeutics (RGLS)	2025	391.88%
NETCLASS TECHNOLOGY INC Class A Ordinary Shares (NTCL)	2025	384.59%
Yoshiharu Global (YOSH)	2025	372.73%
Webull Corporation Incentive Warrant (BULLZ)	2025	352.38%