Know Labs (KNW) had the highest return in the 2000s by a US stock, returning 1,068,548.9%.

ASSET	DECADE	% RETURN
Know Labs (KNW)	2000s	1,068,548.85%
Danaos (DAC)	2000s	811,095.38%
Perspective Therapeutics (CATX)	2000s	296,566.67%
National Grid PLC ADR (NGG)	2000s	212,697.67%
Ring Energy (REI)	2000s	133,233.33%
Gulf Resources (GURE)	2000s	58,200%
Northern Oil & Gas (NOG)	2000s	42,955.19%
India Globalization Capital (IGC)	2000s	25,408.32%
Future Fintech (FTFT)	2000s	20,500%
TherapeuticsMD (TXMD)	2000s	19,503.88%
Frontline (FRO)	2000s	18,583.41%
First Majestic Silver (AG)	2000s	17,196.89%
Ainos (AIMD)	2000s	15,428.85%
Companhia Siderurgica Nacional ADR (SID)	2000s	12,673.16%
Houston American Energy (HUSA)	2000s	12,534.48%
MAG Silver (MAG)	2000s	11,318.95%
Broadwind Energy (BWEN)	2000s	9,608.39%
MEDIFAST (MED)	2000s	8,793.12%
Monster Beverage (MNST)	2000s	7,074.89%
BRF SA ADR (BRFS)	2000s	5,806.86%
Clean Harbors (CLH)	2000s	4,790.88%
Amedisys (AMED)	2000s	4,612.96%
Banco Bradesco SA ADR (BBD)	2000s	4,186.93%
Deckers Outdoor (DECK)	2000s	3,775.93%
Oramed Pharmaceuticals (ORMP)	2000s	3,631.86%