Regencell Bioscience (RGC) has had the highest return this year by a US stock, returning 17,163.8%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	17,163.78%
Kindly MD, Inc Warrants (KDLYW)	2025	9,775%
Kindly (NAKAW)	2025	9,193.75%
DeFi Development (DFDV)	2025	2,502.17%
Maiden (MHLD)	2025	1,900%
HCM II Acquisition (HONDW)	2025	1,839.66%
Kindly (NAKA)	2025	1,722.58%
Kindly MD, Inc Common Stock (KDLY)	2025	1,722.58%
Mobile Global Esports (MGAM)	2025	1,400%
Asset Entities Inc Class B Common Stock (ASST)	2025	1,302%
Diginex Limited Ordinary Shares (DGNX)	2025	1,163.15%
Protagenic Therapeutics (PTIXW)	2025	1,003.08%
Oncology Institute (TOI)	2025	942.48%
Global Interactive Technologies (GITS)	2025	900%
Sharplink Gaming (SBET)	2025	898.7%
M3-Brigade Acquisition V Corp Warrant (MBAVW)	2025	854.51%
Oncology Institute (TOIIW)	2025	790.48%
TMC the metals company Inc Warrants (TMCWW)	2025	777.36%
Webull Corporation Warrants (BULLW)	2025	557.43%
Abits (ABTS)	2025	542.63%
Top KingWin (WAI)	2025	443.86%
Nutex Health (NUTX)	2025	423.7%
LZ Technology Holdings Limited Class B Ordinary Shares (LZMH)	2025	418.59%
ThredUp (TDUP)	2025	400%
Regulus Therapeutics (RGLS)	2025	395.63%