QXO (QXO) had the highest return between 2009 and 2012 by a large-cap US stock, returning 4,032,075%.

ASSET	YEARS	% RETURN
QXO (QXO)	2009-2012	4,032,075%
Jazz Pharmaceuticals (JAZZ)	2009-2012	2,747.59%
Sirius XM (SIRI)	2009-2012	2,352.49%
Lululemon Athletica (LULU)	2009-2012	1,817.74%
Nova (NVMI)	2009-2012	1,350.91%
Onto Innovation (ONTO)	2009-2012	1,153.91%
Ulta Beauty (ULTA)	2009-2012	1,095.65%
Domino's Pizza Inc Common Stock (DPZ)	2009-2012	896.98%
Regeneron Pharmaceuticals (REGN)	2009-2012	828.72%
Las Vegas Sands (LVS)	2009-2012	750.32%
Cheniere Energy Partners (CQP)	2009-2012	740.28%
Booking (BKNG)	2009-2012	735.32%
Teck Resources Ltd Class B (TECK)	2009-2012	674.9%
Baidu (BIDU)	2009-2012	659.77%
Seagate Technology (STX)	2009-2012	634.99%
TFI International (TFII)	2009-2012	604.3%
Tenet Healthcare (THC)	2009-2012	587.92%
Ambev SA ADR (ABEV)	2009-2012	578.98%
Cheniere Energy (LNG)	2009-2012	561.27%
Apple (AAPL)	2009-2012	525.16%
Chart Industries (GTLS)	2009-2012	519.79%
Williams-Sonoma (WSM)	2009-2012	512.87%
HF Sinclair (DINO)	2009-2012	511.06%
Ford Motor (F)	2009-2012	473.34%
Wheaton Precious Metals (WPM)	2009-2012	473.19%

Large-cap stocks are treated as having a market cap of $10B+.