Micron Technology (MU) has had the highest return between 2022 and 2026 by a mega-cap US stock, returning 793.8%.

ASSET	YEARS	% RETURN
Micron Technology (MU)	2022-2026	793.81%
GE Vernova LLC (GEV)	2022-2026	723.8%
Dell Technologies (DELL)	2022-2026	668.58%
Palantir Technologies (PLTR)	2022-2026	572.82%
NVIDIA (NVDA)	2022-2026	562.86%
GE Aerospace (GE)	2022-2026	526.69%
Broadcom (AVGO)	2022-2026	519.41%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2022-2026	376.72%
Arista Networks (ANET)	2022-2026	371.12%
Eli Lilly and (LLY)	2022-2026	363.26%
KLA (KLAC)	2022-2026	362.94%
HSBC Holdings PLC ADR (HSBC)	2022-2026	348.3%
Caterpillar (CAT)	2022-2026	339.63%
Arm Holdings plc American Depositary Shares (ARM)	2022-2026	336.26%
Lam Research (LRCX)	2022-2026	292.02%
Palo Alto Networks (PANW)	2022-2026	242.74%
Taiwan Semiconductor Manufacturing (TSM)	2022-2026	238.29%
Applied Materials (AMAT)	2022-2026	213.97%
Advanced Micro Devices (AMD)	2022-2026	213.23%
Goldman Sachs (GS)	2022-2026	196.84%
Exxon Mobil (XOM)	2022-2026	192.01%
RTX (RTX)	2022-2026	180.13%
Philip Morris International (PM)	2022-2026	159.69%
Citigroup (C)	2022-2026	153.69%
JPMorgan Chase (JPM)	2022-2026	151.78%

Mega-cap stocks are treated as having a market cap of $200B+.