Houston American Energy (HUSA) had the highest return between 2001 and 2003 by a US stock, returning 182,369.6%.

ASSET	YEARS	% RETURN
Houston American Energy (HUSA)	2001-2003	182,369.65%
MEDIFAST (MED)	2001-2003	9,931.58%
Brainstorm Cell Therapeutics (BCLI)	2001-2003	4,605.93%
China Yuchai International (CYD)	2001-2003	4,372.4%
Ziff Davis (ZD)	2001-2003	4,306.81%
Encore Capital (ECPG)	2001-2003	4,214.29%
Versus Systems Inc. (VS)	2001-2003	3,900%
TherapeuticsMD (TXMD)	2001-2003	3,650%
Xcel Brands (XELB)	2001-2003	3,400%
USANA Health Sciences (USNA)	2001-2003	3,397.94%
Odyssey Marine Exploration (OMEX)	2001-2003	3,233.33%
PetMed Express (PETS)	2001-2003	2,780.19%
SigmaTron International (SGMA)	2001-2003	1,990.4%
Tractor Supply (TSCO)	2001-2003	1,735.05%
Sleep Number (SNBR)	2001-2003	1,622.51%
Stratasys (SSYS)	2001-2003	1,513%
Hecla Mining (HL)	2001-2003	1,373.64%
Sohu (SOHU)	2001-2003	1,238.61%
Future Fintech (FTFT)	2001-2003	1,200%
John B Sanfilippo & Son (JBSS)	2001-2003	1,196.25%
Anika Therapeutics (ANIK)	2001-2003	1,146.64%
Companhia Siderurgica Nacional ADR (SID)	2001-2003	1,133.98%
Live Ventures (LIVE)	2001-2003	1,095.83%
ProPhase Labs (PRPH)	2001-2003	1,094.62%
NetEase (NTES)	2001-2003	1,081.62%