InterContinental Hotels Group PLC ADR (IHG) had the highest return in the 2000s by a US stock, returning 9,928,700%.

ASSET	DECADE	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000s	9,928,700%
QVC (QVCGA)	2000s	5,621,098.15%
Northern Oil & Gas (NOG)	2000s	3,882,411.54%
India Globalization Capital (IGC)	2000s	2,299,900%
Houston American Energy (HUSA)	2000s	1,598,586.28%
National Grid PLC ADR (NGG)	2000s	1,161,476.47%
Know Labs (KNW)	2000s	1,068,548.85%
Hirequest (HQI)	2000s	935,500%
Natwest (NWG)	2000s	590,100%
Perspective Therapeutics (CATX)	2000s	296,566.67%
Ring Energy (REI)	2000s	133,233.33%
Ocean Power Technologies (OPTT)	2000s	100,011.11%
Gulf Resources (GURE)	2000s	58,200%
OPTIMIZERx (OPRX)	2000s	56,000%
Gyre Therapeutics (GYRE)	2000s	44,215.31%
Future Fintech (FTFT)	2000s	20,500%
ImmunoPrecise Antibodies (HYFT)	2000s	20,471.43%
TherapeuticsMD (TXMD)	2000s	19,503.88%
First Majestic Silver (AG)	2000s	17,180.89%
Companhia Siderurgica Nacional ADR (SID)	2000s	12,673.16%
NanoViricides (NNVC)	2000s	11,800%
Broadwind Energy (BWEN)	2000s	9,608.39%
MEDIFAST (MED)	2000s	8,793.12%
Monster Beverage (MNST)	2000s	7,074.89%
Weatherford International (WFRD)	2000s	6,000%