Inseego (INSG) had the best year in 2000 by a US stock in 2000, returning 3,093,650%.

ASSET	YEAR	% RETURN
Insmed (INSM)	2000	45,007.28%
FuelCell Energy (FCEL)	2000	452.64%
Flexible Solutions International (FSI)	2000	472.41%
Sanara Medtech (SMTI)	2000	650%
Inseego (INSG)	2000	3,093,650%