Northern Oil & Gas (NOG) had the highest return between 2000 and 2010 by a US stock, returning 8,777,303.8%.

ASSET	YEARS	% RETURN
Northern Oil & Gas (NOG)	2000-2010	8,777,303.85%
Cemtrex (CETX)	2000-2010	4,938,903.31%
Houston American Energy (HUSA)	2000-2010	4,701,043.45%
Hirequest (HQI)	2000-2010	2,131,400%
Taoping (TAOP)	2000-2010	1,250,383.37%
NextTrip (NTRP)	2000-2010	1,199,900%
India Globalization Capital (IGC)	2000-2010	966,566.67%
Perspective Therapeutics (CATX)	2000-2010	376,566.67%
Aris Mining (ARMN)	2000-2010	326,680.13%
Inseego (INSG)	2000-2010	159,066.67%
Ring Energy (REI)	2000-2010	133,233.33%
DeFi Technologies (DEFT)	2000-2010	65,800%
Ocean Power Technologies (OPTT)	2000-2010	63,455.56%
ProMIS Neurosciences (PMN)	2000-2010	54,572.9%
Alto Ingredients (ALTO)	2000-2010	52,804.13%
Pioneer Power Solutions (PPSI)	2000-2010	29,429.23%
NanoViricides (NNVC)	2000-2010	20,480%
Frontline (FRO)	2000-2010	18,505.37%
Companhia Siderurgica Nacional ADR (SID)	2000-2010	13,662.3%
ImmunoPrecise Antibodies (HYFT)	2000-2010	11,900%
Monster Beverage (MNST)	2000-2010	9,668.39%
Deckers Outdoor (DECK)	2000-2010	9,015.23%
MEDIFAST (MED)	2000-2010	8,298.73%
Americas Silver (USAS)	2000-2010	7,873.68%
Franklin Wireless (FKWL)	2000-2010	6,851.41%