Azitra (AZTR) had the highest return between 2021 and 2023 by a US stock, returning 3,285,614.3%.

ASSET	YEARS	% RETURN
Azitra (AZTR)	2021-2023	3,285,614.29%
Brera Holdings PLC Class B Ordinary Shares (BREA)	2021-2023	1,311,900%
NioCorp Developments Ltd Common Stock (NB)	2021-2023	531,566.67%
MDxHealth SA ADR (MDXH)	2021-2023	358,081.82%
BioNexus Gene Lab Corp Common stock (BGLC)	2021-2023	230,334.78%
Lottery (SEGG)	2021-2023	44,693.39%
MicroCloud Hologram (HOLO)	2021-2023	20,476.39%
Diversified Energy (DEC)	2021-2023	18,567.52%
Applied Digital (APLD)	2021-2023	17,873.33%
Castellum (CTM)	2021-2023	6,672.73%
Atlas Lithium Corporation Common Stock (ATLX)	2021-2023	4,070.67%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2021-2023	3,329.36%
Alpha Metallurgical Resources (AMR)	2021-2023	3,045.55%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	2021-2023	3,000.63%
Destination XL (DXLG)	2021-2023	1,579.39%
Weatherford International (WFRD)	2021-2023	1,548.36%
RCM Technologies (RCMT)	2021-2023	1,330.54%
Hudson Technologies (HDSN)	2021-2023	1,172.64%
Vivid Seats (SEAT)	2021-2023	1,166.51%
Sigma Lithium Resources (SGML)	2021-2023	1,161.2%
Cresud SACIF y A Warrant (CRESW)	2021-2023	1,060.2%
Vista Oil Gas ADR (VIST)	2021-2023	1,039.38%
Aehr Test Systems (AEHR)	2021-2023	961.2%
Obsidian Energy (OBE)	2021-2023	911.94%
Peabody Energy (BTU)	2021-2023	898.49%