Azitra (AZTR) had the highest return between 2021 and 2023 by a US stock, returning 3,285,614.3%.

ASSET	YEARS	% RETURN
Azitra (AZTR)	2021-2023	3,285,614.29%
MKDWELL Tech Inc Ordinary Share (MKDW)	2021-2023	2,812,400%
MDxHealth SA ADR (MDXH)	2021-2023	358,081.82%
BioNexus Gene Lab Corp Common stock (BGLC)	2021-2023	230,334.78%
Agape ATP Corporation Common Stock (ATPC)	2021-2023	170,300%
Heart Test Laboratories Inc Common Stock (HSCS)	2021-2023	50,194.12%
Lottery (SEGG)	2021-2023	44,693.39%
Guardforce AI (GFAI)	2021-2023	15,861.54%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	2021-2023	7,311.76%
Castellum (CTM)	2021-2023	6,672.73%
Prestige Wealth (AURE)	2021-2023	4,229.9%
Atlas Lithium Corporation Common Stock (ATLX)	2021-2023	4,070.67%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2021-2023	3,329.36%
Alpha Metallurgical Resources (AMR)	2021-2023	3,045.55%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	2021-2023	3,000.63%
Applied Digital (APLD)	2021-2023	2,895.56%
Destination XL (DXLG)	2021-2023	1,579.39%
Weatherford International (WFRD)	2021-2023	1,548.37%
RCM Technologies (RCMT)	2021-2023	1,330.54%
Hudson Technologies (HDSN)	2021-2023	1,172.64%
Vivid Seats (SEAT)	2021-2023	1,166.51%
Sigma Lithium Resources (SGML)	2021-2023	1,161.2%
Vista Oil Gas ADR (VIST)	2021-2023	1,039.38%
Aehr Test Systems (AEHR)	2021-2023	961.2%
Obsidian Energy (OBE)	2021-2023	911.94%