Integra Resources (ITRG) has had the highest return since 2020 by a US stock, returning 663,233.3%.

ASSET	% RETURN
Integra Resources (ITRG)	663,233.33%
SharonAI Holdings, Inc Class A Common Stock (SHAZ)	449,130.77%
MDxHealth SA ADR (MDXH)	304,445.45%
Everbright Digital Holding Limited Ordinary Shares (EDHL)	259,900%
Synergy CHC Corp Common Stock (SNYR)	221,566.67%
DevvStream Corp Common Stock (DEVS)	78,500%
BioNexus Gene Lab Corp Common stock (BGLC)	61,607.32%
Applied Digital (APLD)	60,432.41%
COSCIENS Biopharma (CSCI)	39,222.03%
MKDWELL Tech Inc Ordinary Share (MKDW)	21,715.18%
Castellum (CTM)	17,238.18%
Mingteng International Corporation Inc Ordinary Shares (MTEN)	8,642.86%
Heart Test Laboratories Inc Common Stock (HSCS)	7,607.35%
Regencell Bioscience (RGC)	7,496.58%
Perpetua Resources (PPTA)	7,215.57%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	6,637.16%
Cybin (CYBN)	3,925.51%
QMMM Holdings Limited Ordinary Shares (QMMM)	3,880%
TechCreate (TCGL)	3,740.89%
Innodata (INOD)	3,735.09%
IsoEnergy (ISOU)	3,674.46%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	3,457.42%
Azitra (AZTR)	3,012.5%
Celestica (CLS)	2,992.06%
NVIDIA (NVDA)	2,930.02%