Regencell Bioscience (RGC) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 16,165%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	16,164.97%
SRM Entertainment, Inc Common Stock (SRM)	2025	1,291.47%
Kindly MD, Inc Common Stock (KDLY)	2025	1,038.71%
Asset Entities Inc Class B Common Stock (ASST)	2025	842%
Oncology Institute (TOI)	2025	602.61%
mF International Limited Ordinary Shares (MFI)	2025	595.65%
TMC the metals (TMC)	2025	557.02%
Aeva Technologies, Inc Common Stock (AEVA)	2025	500.21%
Abits (ABTS)	2025	495.61%
Global Interactive Technologies (GITS)	2025	493.36%
Dominari (DOMH)	2025	489.36%
ThredUp (TDUP)	2025	440.28%
Regulus Therapeutics (RGLS)	2025	410%
Oriental Culture Holding (OCG)	2025	398.32%
Vigil Neuroscience (VIGL)	2025	367.65%
QuantaSing Group Limited American Depositary Shares (QSG)	2025	322.62%
Allied Gaming & Entertainment (AGAE)	2025	307.89%
Roma Green Finance Limited Ordinary Shares (ROMA)	2025	300%
Pheton Holdings Ltd Class A Ordinary Shares (PTHL)	2025	297.22%
Curiositystream (CURI)	2025	279.91%
Mobile-health Network Solutions Class A Ordinary Shares (MNDR)	2025	278.74%
Rapid Micro Biosystems (RPID)	2025	276.92%
Nutex Health (NUTX)	2025	276.49%
ABVC BioPharma (ABVC)	2025	259.32%
Sezzle Inc Common Stock (SEZL)	2025	256.51%