ReShape Lifesciences (RSLS) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 92,400%.

ASSET	YEAR	% RETURN
ReShape Lifesciences (RSLS)	2025	92,400%
Regencell Bioscience (RGC)	2025	7,104.92%
Asset Entities Inc Class B Common Stock (ASST)	2025	1,524%
Janover Inc Common Stock (JNVR)	2025	1,491.72%
Abits (ABTS)	2025	1,218.18%
Oncology Institute (TOI)	2025	815.03%
Dominari (DOMH)	2025	536.08%
Global Interactive Technologies (GITS)	2025	526.56%
Oriental Culture Holding (OCG)	2025	505.04%
Alzamend Neuro (ALZN)	2025	406.23%
Regulus Therapeutics (RGLS)	2025	391.88%
NETCLASS TECHNOLOGY INC Class A Ordinary Shares (NTCL)	2025	384.59%
Yoshiharu Global (YOSH)	2025	372.73%
ThredUp (TDUP)	2025	332.64%
Mobile-health Network Solutions Class A Ordinary Shares (MNDR)	2025	321.5%
Nutex Health (NUTX)	2025	276.93%
CervoMed (CRVO)	2025	253.75%
Rapid Micro Biosystems (RPID)	2025	238.46%
Curiositystream (CURI)	2025	231.41%
VivoPower International (VVPR)	2025	222.22%
Kindly MD, Inc Common Stock (KDLY)	2025	214.52%
Cantor Equity Partners, Inc Class A Ordinary Shares (CEP)	2025	203.27%
QuantaSing Group Limited American Depositary Shares (QSG)	2025	203.17%
Junee Limited Ordinary Shares (JUNE)	2025	202.43%
DBV Technologies (DBVT)	2025	198.78%