Integra Resources (ITRG) has had the highest return since 2020 by a US stock, returning 596,566.7%.

ASSET	% RETURN
Integra Resources (ITRG)	596,566.67%
MDxHealth SA ADR (MDXH)	334,445.45%
Everbright Digital Holding Limited Ordinary Shares (EDHL)	284,900%
Synergy CHC Corp Common Stock (SNYR)	283,233.33%
DevvStream Corp Common Stock (DEVS)	84,400%
Applied Digital (APLD)	73,765.74%
BioNexus Gene Lab Corp Common stock (BGLC)	55,509.76%
COSCIENS Biopharma (CSCI)	45,832.2%
MKDWELL Tech Inc Ordinary Share (MKDW)	18,650%
Castellum (CTM)	16,576.36%
Regencell Bioscience (RGC)	10,001.33%
Mingteng International Corporation Inc Ordinary Shares (MTEN)	9,385.71%
Heart Test Laboratories Inc Common Stock (HSCS)	8,626.47%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	6,848.64%
QMMM Holdings Limited Ordinary Shares (QMMM)	3,880%
Innodata (INOD)	3,810.53%
TechCreate (TCGL)	3,740.89%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	3,737.54%
Cybin (CYBN)	3,522.45%
Celestica (CLS)	3,406.62%
IsoEnergy (ISOU)	3,385.9%
NVIDIA (NVDA)	3,063.47%
Centrus Energy (LEU)	2,903.92%
DeFi Technologies (DEFT)	2,870.59%
Azitra (AZTR)	2,864.29%