Arrowhead Pharmaceuticals (ARWR) had the lowest return in November 2016 by a large-cap US stock, returning -75.2%.

ASSET	MONTH	% RETURN
Arrowhead Pharmaceuticals (ARWR)	November 2016	-75.17%
Harmony Gold Mining (HMY)	November 2016	-30.27%
Gold Fields Ltd ADR (GFI)	November 2016	-28.1%
Tenet Healthcare (THC)	November 2016	-26.25%
Wheaton Precious Metals (WPM)	November 2016	-26.22%
First Solar (FSLR)	November 2016	-25.26%
AngloGold Ashanti (AU)	November 2016	-21.69%
Applied Digital (APLD)	November 2016	-20.73%
Alamos Gold (AGI)	November 2016	-20.62%
Agnico Eagle Mines (AEM)	November 2016	-20.46%
Tyson Foods (TSN)	November 2016	-19.14%
Fomento Economico Mexicano (FMX)	November 2016	-18.82%
Ferrovial SE (FER)	November 2016	-17.37%
Kinross Gold (KGC)	November 2016	-17.34%
Coca-Cola Femsa SAB de CV ADR (KOF)	November 2016	-16.7%
QXO (QXO)	November 2016	-16.42%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	November 2016	-16.35%
Coeur Mining (CDE)	November 2016	-16.31%
DexCom (DXCM)	November 2016	-16.24%
Banco Bradesco SA ADR (BBD)	November 2016	-16.21%
Globalstar, Inc Common Stock (GSAT)	November 2016	-15.05%
Coca-Cola Europacific Partners (CCEP)	November 2016	-15%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	November 2016	-14.92%
TIM Participacoes (TIMB)	November 2016	-14.91%
Corpay (CPAY)	November 2016	-14.89%

Large-cap stocks are treated as having a market cap of $10B+.