Insmed (INSM) had the lowest return in September 2002 by a large-cap US stock, returning -78%.

ASSET	MONTH	% RETURN
Insmed (INSM)	September 2002	-77.96%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	September 2002	-47.06%
United Rentals (URI)	September 2002	-45.37%
Centrais Electricas Brasileiras (EBR)	September 2002	-44.6%
AXIA Energia (AXIA)	September 2002	-44.06%
Celestica (CLS)	September 2002	-41.52%
Manhattan Associates (MANH)	September 2002	-38.82%
ASML Holding NV ADR (ASML)	September 2002	-38.47%
F5 Networks (FFIV)	September 2002	-38.37%
Fidelity National Information Services (FIS)	September 2002	-38.36%
Advanced Micro Devices (AMD)	September 2002	-37.91%
Booking (BKNG)	September 2002	-37.61%
Carpenter Technology (CRS)	September 2002	-37.5%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	September 2002	-37.5%
SAP SE ADR (SAP)	September 2002	-36.55%
Banco Bradesco SA ADR (BBD)	September 2002	-35.82%
ON Semiconductor (ON)	September 2002	-35.27%
CAE (CAE)	September 2002	-33.35%
Tower Semiconductor (TSEM)	September 2002	-33.33%
ING Group NV ADR (ING)	September 2002	-33.08%
Petroleo Brasileiro Petrobras SA ADR (PBR)	September 2002	-32.51%
Itau Unibanco Banco (ITUB)	September 2002	-32.25%
Aegon NV ADR (AEG)	September 2002	-31.47%
STMicroelectronics NV ADR (STM)	September 2002	-30.65%
Trimble (TRMB)	September 2002	-29.18%

Large-cap stocks are treated as having a market cap of $10B+.