worst performing small stocks 2010 to 2025

Palisade Bio (PALI) had the lowest return between 2010 and 2025 by a small-cap US stock, returning -100%.

ASSETYEARS% RETURN
Palisade Bio (PALI)
2010-2025
-100%
Blue Ridge Bankshares (BRBS)
2010-2025
-100%
FVCBankcorp (FVCB)
2010-2025
-100%
Gevo (GEVO)
2010-2025
-100%
Seanergy Maritime (SHIP)
2010-2025
-100%
MVB Financial (MVBF)
2010-2025
-100%
Amalgamated Bank (AMAL)
2010-2025
-100%
UTime (FXHO)
2010-2025
-99.99%
Verb Technology (VERB)
2010-2025
-99.99%
American Bitcoin (ABTC)
2010-2025
-99.99%
Achieve Life Sciences (ACHV)
2010-2025
-99.99%
FuelCell Energy (FCEL)
2010-2025
-99.96%
Gyre Therapeutics (GYRE)
2010-2025
-99.95%
Eightco (ORBS)
2010-2025
-99.95%
Avalo Therapeutics (AVTX)
2010-2025
-99.9%
Abeona Therapeutics (ABEO)
2010-2025
-99.87%
X4 Pharmaceuticals (XFOR)
2010-2025
-99.83%
Ocugen (OCGN)
2010-2025
-99.8%
Red Cat (RCAT)
2010-2025
-99.56%
Elemental Royalty (ELE)
2010-2025
-99.41%
Opus Genetics (IRD)
2010-2025
-99.37%
Barnes & Noble Education (BNED)
2010-2025
-99.34%
P3 Health Partners (PIII)
2010-2025
-99.3%
Q32 Bio (QTTB)
2010-2025
-99.2%
Sharplink Gaming (SBET)
2010-2025
-99.13%
Small-cap stocks are treated as having a market cap between $300M and $2B.

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