Orange County Bancorp (OBT) had the lowest return between 2003 and 2004 by a US stock, returning -100%.

ASSET	YEARS	% RETURN
Orange County Bancorp (OBT)	2003-2004	-100%
Millicom International Cellular (TIGO)	2003-2004	-100%
Ainos (AIMD)	2003-2004	-99.61%
Zynex (ZYXI)	2003-2004	-99.4%
Flux Power (FLUX)	2003-2004	-97.14%
Algorhythm (RIME)	2003-2004	-92.2%
Marker Therapeutics (MRKR)	2003-2004	-89.01%
Cerus (CERS)	2003-2004	-86.19%
Zivo Bioscience (ZIVO)	2003-2004	-83.08%
Liberty Global PLC Class B (LBTYB)	2003-2004	-82.8%
Franklin Wireless (FKWL)	2003-2004	-80%
Lendway (LDWY)	2003-2004	-79.14%
Riley Exploration Permian (REPX)	2003-2004	-78.33%
QXO (QXO)	2003-2004	-78%
Heritage Global (HGBL)	2003-2004	-76.92%
Applied Digital (APLD)	2003-2004	-76.11%
NeoGenomics (NEO)	2003-2004	-75%
Travere Therapeutics (TVTX)	2003-2004	-73.85%
PriceSmart (PSMT)	2003-2004	-68.53%
Raytech Holding Limited Ordinary Shares (RAY)	2003-2004	-68.28%
Cyclacel Pharmaceuticals (CYCC)	2003-2004	-67.53%
Riot Blockchain (RIOT)	2003-2004	-67.5%
SPAR (SGRP)	2003-2004	-66.77%
EXACT Sciences (EXAS)	2003-2004	-65.15%
Mitek Systems (MITK)	2003-2004	-62.84%