InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2000 and 2003 by a large-cap US stock, returning 5,929,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000-2003	5,929,900%
Axon Enterprise (AXON)	2000-2003	1,076.79%
NVR (NVR)	2000-2003	875.92%
Tractor Supply (TSCO)	2000-2003	870.61%
Deckers Outdoor (DECK)	2000-2003	681.14%
Tapestry (TPR)	2000-2003	654.99%
Clean Harbors (CLH)	2000-2003	631.05%
Altria (MO)	2000-2003	560.21%
Lennar (LEN)	2000-2003	559.7%
Royal Gold (RGLD)	2000-2003	502.68%
Chunghwa Telecom (CHT)	2000-2003	501.4%
DR Horton (DHI)	2000-2003	493.19%
East West Bancorp (EWBC)	2000-2003	403.96%
Old Dominion Freight Line (ODFL)	2000-2003	375.53%
Quest Diagnostics (DGX)	2000-2003	374.55%
UnitedHealth (UNH)	2000-2003	338.86%
CACI International (CACI)	2000-2003	329.79%
Toll Brothers (TOL)	2000-2003	326.95%
PulteGroup (PHM)	2000-2003	323.34%
Pool (POOL)	2000-2003	314.25%
Gilead Sciences (GILD)	2000-2003	308.07%
Cameco (CCJ)	2000-2003	300.86%
Laboratory Corporation of America (LH)	2000-2003	300.82%
Dick’s Sporting Goods (DKS)	2000-2003	297.54%
Renaissancere (RNR)	2000-2003	289.8%

Large-cap stocks are treated as having a market cap of $10B+.