InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2000 and 2003 by a US stock, returning 5,929,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000-2003	5,929,900%
Hirequest (HQI)	2000-2003	5,833,550%
Houston American Energy (HUSA)	2000-2003	182,369.65%
ImmunoPrecise Antibodies (HYFT)	2000-2003	122,042.86%
Inseego (INSG)	2000-2003	99,733.33%
Insmed (INSM)	2000-2003	38,521.59%
Flux Power (FLUX)	2000-2003	7,028.66%
Flexible Solutions International (FSI)	2000-2003	4,032.97%
MEDIFAST (MED)	2000-2003	4,000.5%
TherapeuticsMD (TXMD)	2000-2003	3,650%
China Yuchai International (CYD)	2000-2003	3,505.67%
Xcel Brands (XELB)	2000-2003	3,400%
Odyssey Marine Exploration (OMEX)	2000-2003	1,900%
American Vanguard (AVD)	2000-2003	1,526.47%
Hovnanian Enterprises (HOV)	2000-2003	1,279.17%
CarMax (KMX)	2000-2003	1,274.67%
Future Fintech (FTFT)	2000-2003	1,200%
John B Sanfilippo & Son (JBSS)	2000-2003	1,175.98%
Avadel Pharmaceuticals (AVDL)	2000-2003	1,160.71%
USANA Health Sciences (USNA)	2000-2003	1,159.47%
BJs Restaurants (BJRI)	2000-2003	1,156.47%
Meritage (MTH)	2000-2003	1,133.63%
Axon Enterprise (AXON)	2000-2003	1,076.79%
SunOpta (STKL)	2000-2003	1,036%
Cal-Maine Foods (CALM)	2000-2003	964.7%