NVIDIA (NVDA) had the highest return between 2019 and 2024 by a mega-cap US stock, returning 4,045.1%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2019-2024	4,045.1%
Tesla (TSLA)	2019-2024	1,878.96%
Broadcom (AVGO)	2019-2024	1,014.33%
Arista Networks (ANET)	2019-2024	762.67%
KLA (KLAC)	2019-2024	685.89%
Palantir Technologies (PLTR)	2019-2024	656.3%
Eli Lilly and (LLY)	2019-2024	633.59%
Marvell Technology (MRVL)	2019-2024	618.32%
Apple (AAPL)	2019-2024	577.08%
Advanced Micro Devices (AMD)	2019-2024	570.68%
Taiwan Semiconductor Manufacturing (TSM)	2019-2024	528.34%
Palo Alto Networks (PANW)	2019-2024	490.01%
Lam Research (LRCX)	2019-2024	488.07%
Applied Materials (AMAT)	2019-2024	441.61%
Dell Technologies (DELL)	2019-2024	405.24%
Costco Wholesale (COST)	2019-2024	402.14%
GE Aerospace (GE)	2019-2024	378.86%
ASML Holding NV ADR (ASML)	2019-2024	377.25%
Facebook (META)	2019-2024	355.65%
Microsoft (MSFT)	2019-2024	349.21%
Oracle (ORCL)	2019-2024	311.61%
Goldman Sachs (GS)	2019-2024	301.95%
Morgan Stanley (MS)	2019-2024	289.7%
Alphabet Inc Class A (GOOGL)	2019-2024	269.91%
T-Mobile US (TMUS)	2019-2024	257.82%

Mega-cap stocks are treated as having a market cap of $200B+.