Tesla (TSLA) had the highest return between 2010 and 2014 by a mega-cap US stock, returning 1,070.5%.

ASSET	YEARS	% RETURN
Tesla (TSLA)	2010-2014	1,070.55%
Netflix (NFLX)	2010-2014	515.32%
Broadcom (AVGO)	2010-2014	489.4%
Seagate Technology (STX)	2010-2014	315.23%
Home Depot (HD)	2010-2014	307.6%
Apple (AAPL)	2010-2014	282.28%
UnitedHealth (UNH)	2010-2014	246.13%
Mastercard (MA)	2010-2014	239.55%
Micron Technology (MU)	2010-2014	223.57%
Visa Inc Class A (V)	2010-2014	209.4%
Amgen (AMGN)	2010-2014	200.76%
ASML Holding NV New York Registry Shares (ASML)	2010-2014	197.39%
KLA (KLAC)	2010-2014	174.9%
Costco Wholesale (COST)	2010-2014	172.26%
Thermo Fisher Scientific (TMO)	2010-2014	166.42%
American Express (AXP)	2010-2014	144.81%
Eli Lilly and (LLY)	2010-2014	141.34%
Amphenol (APH)	2010-2014	135.09%
Texas Instruments (TXN)	2010-2014	129.13%
Amazon (AMZN)	2010-2014	127.78%
Berkshire Hathaway (BRK.B)	2010-2014	127.5%
Berkshire Hathaway (BRK.A)	2010-2014	127.48%
Wells Fargo (WFC)	2010-2014	125.75%
Taiwan Semiconductor Manufacturing (TSM)	2010-2014	123.84%
Palo Alto Networks (PANW)	2010-2014	122.25%

Mega-cap stocks are treated as having a market cap of $200B+.