NVIDIA (NVDA) had the highest return between 2018 and 2024 by a mega-cap US stock, returning 2,673.7%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2018-2024	2,673.71%
Tesla (TSLA)	2018-2024	1,841.54%
Advanced Micro Devices (AMD)	2018-2024	1,059.21%
Broadcom (AVGO)	2018-2024	1,002.03%
Eli Lilly and (LLY)	2018-2024	922.08%
Palantir Technologies (PLTR)	2018-2024	656.3%
Arista Networks (ANET)	2018-2024	650.69%
Palo Alto Networks (PANW)	2018-2024	647.78%
KLA (KLAC)	2018-2024	568.29%
Apple (AAPL)	2018-2024	525.58%
Taiwan Semiconductor Manufacturing (TSM)	2018-2024	481.48%
Costco Wholesale (COST)	2018-2024	443.37%
Dell Technologies (DELL)	2018-2024	439.96%
Crowdstrike (CRWD)	2018-2024	438.83%
Marvell Technology (MRVL)	2018-2024	434.08%
Microsoft (MSFT)	2018-2024	428.19%
Netflix (NFLX)	2018-2024	354.52%
Lam Research (LRCX)	2018-2024	333.18%
ASML Holding NV ADR (ASML)	2018-2024	326.56%
Oracle (ORCL)	2018-2024	291.06%
Amazon (AMZN)	2018-2024	274.39%
Alphabet Inc Class A (GOOGL)	2018-2024	260.84%
Mastercard (MA)	2018-2024	260.15%
Novo Nordisk A-S (NVO)	2018-2024	258.71%
Applied Materials (AMAT)	2018-2024	241.19%

Mega-cap stocks are treated as having a market cap of $200B+.