Nordson (NDSN) had the highest return between 2009 and 2022 by a large-cap US stock when the return was < 1,600%, returning 1,599.2%.

ASSET	YEARS	% RETURN
Nordson (NDSN)	2009-2022	1,599.24%
Thermo Fisher Scientific (TMO)	2009-2022	1,584.7%
Centene (CNC)	2009-2022	1,571.97%
Salesforce (CRM)	2009-2022	1,552.2%
Edwards Lifesciences (EW)	2009-2022	1,549.13%
Microsoft (MSFT)	2009-2022	1,543.73%
ServiceNow (NOW)	2009-2022	1,534.82%
Constellation Brands Inc Class A (STZ)	2009-2022	1,518.76%
Moodys (MCO)	2009-2022	1,514.46%
Adobe Systems (ADBE)	2009-2022	1,494.1%
Trade Desk (TTD)	2009-2022	1,459.3%
Texas Instruments (TXN)	2009-2022	1,411.87%
Humana (HUM)	2009-2022	1,411.24%
Deckers Outdoor (DECK)	2009-2022	1,404.18%
Coca-Cola Europacific Partners (CCEP)	2009-2022	1,397.42%
DR Horton (DHI)	2009-2022	1,384.63%
Deere (DE)	2009-2022	1,379.27%
Agilent Technologies (A)	2009-2022	1,379.08%
Texas Roadhouse (TXRH)	2009-2022	1,365.51%
CoreSite Realty (COR)	2009-2022	1,353.87%
Elevance Health (ELV)	2009-2022	1,351.97%
Packaging Corp of America (PKG)	2009-2022	1,348.44%
Taiwan Semiconductor Manufacturing (TSM)	2009-2022	1,340.23%
Broadridge Financial Solutions (BR)	2009-2022	1,336.45%
Eli Lilly and (LLY)	2009-2022	1,326.43%

Large-cap stocks are treated as having a market cap of $10B+.