NVIDIA (NVDA) has had the highest return between 2021 and 2025 by a US stock with a market cap of $50B+, returning 1,373.5%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2021-2025	1,373.46%
Vistra Energy (VST)	2021-2025	1,087.2%
Constellation Energy (CEG)	2021-2025	941.78%
Vertiv (VRT)	2021-2025	803.77%
Broadcom (AVGO)	2021-2025	771.24%
Arista Networks (ANET)	2021-2025	770.71%
Applovin (APP)	2021-2025	757.6%
Palantir Technologies Inc Class A Common Stock (PLTR)	2021-2025	675.7%
MicroStrategy (MSTR)	2021-2025	669.32%
Howmet Aerospace (HWM)	2021-2025	571.47%
Quanta Services (PWR)	2021-2025	511.63%
Axon Enterprise (AXON)	2021-2025	496.73%
GE Aerospace (GE)	2021-2025	463.55%
GE Vernova LLC (GEV)	2021-2025	452.62%
Eli Lilly and (LLY)	2021-2025	432.41%
Marathon Petroleum (MPC)	2021-2025	409.73%
Oracle (ORCL)	2021-2025	392.24%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	2021-2025	386.2%
Interactive Brokers (IBKR)	2021-2025	385.21%
Dell Technologies (DELL)	2021-2025	352.79%
McKesson (MCK)	2021-2025	347.64%
Natwest (NWG)	2021-2025	337.15%
United Rentals (URI)	2021-2025	331.71%
KLA-Tencor (KLAC)	2021-2025	323.61%
Royal Caribbean Cruises (RCL)	2021-2025	316.21%