NVIDIA (NVDA) has had the highest return between 2021 and 2025 by a US stock with a market cap of $50B+, returning 1,301.5%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2021-2025	1,301.46%
Vistra Energy (VST)	2021-2025	1,012.91%
Constellation Energy (CEG)	2021-2025	901.71%
Vertiv (VRT)	2021-2025	804.47%
Arista Networks (ANET)	2021-2025	747.98%
Broadcom (AVGO)	2021-2025	719.75%
Applovin (APP)	2021-2025	714.13%
Palantir Technologies Inc Class A Common Stock (PLTR)	2021-2025	633.75%
MicroStrategy (MSTR)	2021-2025	632.09%
Howmet Aerospace (HWM)	2021-2025	554.61%
Quanta Services (PWR)	2021-2025	494.12%
Axon Enterprise (AXON)	2021-2025	471.52%
GE Aerospace (GE)	2021-2025	448.75%
GE Vernova LLC (GEV)	2021-2025	426.73%
Eli Lilly and (LLY)	2021-2025	418.8%
Marathon Petroleum (MPC)	2021-2025	391.61%
Oracle (ORCL)	2021-2025	385.61%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	2021-2025	374.62%
Interactive Brokers (IBKR)	2021-2025	361.09%
McKesson (MCK)	2021-2025	350.94%
Dell Technologies (DELL)	2021-2025	337.17%
Natwest (NWG)	2021-2025	335.34%
United Rentals (URI)	2021-2025	318.32%
Royal Caribbean Cruises (RCL)	2021-2025	312.99%
KLA-Tencor (KLAC)	2021-2025	295.17%