Sandisk (SNDK) has had the highest return between 2025 and 2026 by a large-cap US stock, returning 5,364.7%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2025-2026	5,364.69%
Abivax SA American Depositary Shares (ABVX)	2025-2026	1,832.32%
Western Digital (WDC)	2025-2026	1,193.51%
Micron Technology (MU)	2025-2026	1,056.83%
Bloom Energy (BE)	2025-2026	986.67%
Seagate Technology (STX)	2025-2026	966.72%
Lumentum (LITE)	2025-2026	852.96%
ViaSat (VSAT)	2025-2026	735.91%
Nebius (NBIS)	2025-2026	680.84%
Silicon Motion Technology (SIMO)	2025-2026	521.29%
TTM Technologies (TTMI)	2025-2026	485.99%
Vicor (VICR)	2025-2026	458.39%
Intel (INTC)	2025-2026	442.96%
Ciena (CIEN)	2025-2026	441.58%
Guardant Health (GH)	2025-2026	412.16%
Lam Research (LRCX)	2025-2026	387.16%
Hut 8 Corp Common Stock (HUT)	2025-2026	384.45%
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	2025-2026	376.58%
Millicom International Cellular (TIGO)	2025-2026	360.91%
Advanced Micro Devices (AMD)	2025-2026	356.2%
ASE Industrial Holding Co Ltd ADR (ASX)	2025-2026	345.94%
Tower Semiconductor (TSEM)	2025-2026	328.37%
Revolution Medicines (RVMD)	2025-2026	325.4%
Viavi Solutions (VIAV)	2025-2026	323.6%
BrightSpring Health Services, Inc Common Stock (BTSG)	2025-2026	315.29%

Large-cap stocks are treated as having a market cap of $10B+.