Sandisk (SNDK) has had the highest return between 2025 and 2026 by a large-cap US stock, returning 4,142.2%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2025-2026	4,142.24%
Lumentum (LITE)	2025-2026	1,082.76%
Micron Technology (MU)	2025-2026	1,068.34%
Bloom Energy (BE)	2025-2026	1,065.17%
Seagate Technology (STX)	2025-2026	783.35%
Western Digital (WDC)	2025-2026	759.38%
Nebius (NBIS)	2025-2026	646.75%
Vicor (VICR)	2025-2026	432.43%
Guardant Health (GH)	2025-2026	420.93%
10X Genomics (TXG)	2025-2026	418.55%
Dell Technologies (DELL)	2025-2026	414.16%
Moderna (MRNA)	2025-2026	406.49%
Intel (INTC)	2025-2026	400.99%
ASE Industrial Holding Co Ltd ADR (ASX)	2025-2026	396.84%
Frontline (FRO)	2025-2026	388.66%
Advanced Micro Devices (AMD)	2025-2026	385.93%
Ciena (CIEN)	2025-2026	376.09%
Revolution Medicines (RVMD)	2025-2026	341.5%
TTM Technologies (TTMI)	2025-2026	341.5%
Lam Research (LRCX)	2025-2026	330.92%
AngloGold Ashanti (AU)	2025-2026	328.6%
Tower Semiconductor (TSEM)	2025-2026	316.35%
Viavi Solutions (VIAV)	2025-2026	310.52%
Hut 8 Corp Common Stock (HUT)	2025-2026	303.98%
Grupo Cibest (CIB)	2025-2026	292.32%

Large-cap stocks are treated as having a market cap of $10B+.