AngloGold Ashanti (AU) had the highest return between 1989 and 2005 by a large-cap US stock, returning 10,052,600%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1989-2005	10,052,600%
InterContinental Hotels Group PLC ADR (IHG)	1989-2005	9,399,400%
National Grid PLC ADR (NGG)	1989-2005	864,752.94%
Suncor Energy (SU)	1989-2005	164,532.46%
UnitedHealth (UNH)	1989-2005	44,525.87%
Altria (MO)	1989-2005	26,764.67%
Cisco Systems (CSCO)	1989-2005	22,041.95%
Jack Henry & Associates (JKHY)	1989-2005	21,366.18%
Aegon NV ADR (AEG)	1989-2005	20,919.6%
Best Buy (BBY)	1989-2005	14,023.11%
Hubbell (HUBB)	1989-2005	12,921.58%
Amgen (AMGN)	1989-2005	11,115.99%
Teva Pharma Industries Ltd ADR (TEVA)	1989-2005	11,097.97%
Charles Schwab (SCHW)	1989-2005	10,895.49%
Johnson Controls International (JCI)	1989-2005	10,047.23%
Electronic Arts (EA)	1989-2005	9,893.8%
Insmed (INSM)	1989-2005	9,206.83%
Qualcomm (QCOM)	1989-2005	8,561.57%
Microsoft (MSFT)	1989-2005	7,932.92%
Brown & Brown (BRO)	1989-2005	7,685.93%
Expeditors International of Washington (EXPD)	1989-2005	7,576.2%
Fastenal (FAST)	1989-2005	6,746.12%
Paychex (PAYX)	1989-2005	6,360.8%
Constellation Brands Inc Class A (STZ)	1989-2005	6,195.19%
Cognizant Technology Solutions Corp Class A (CTSH)	1989-2005	5,932.61%

Large-cap stocks are treated as having a market cap of $10B+.