Suzano Papel e Celulose SA ADR (SUZ) had the highest return between 1999 and 2002 by a large-cap US stock, returning 1,088.8%.

ASSET	YEARS	% RETURN
Suzano Papel e Celulose SA ADR (SUZ)	1999-2002	1,088.78%
Clean Harbors (CLH)	1999-2002	857.54%
Royal Gold (RGLD)	1999-2002	590.84%
NVR (NVR)	1999-2002	584.67%
Laboratory Corporation of America (LH)	1999-2002	576.12%
Neurocrine Biosciences (NBIX)	1999-2002	552.29%
Quest Diagnostics (DGX)	1999-2002	541.13%
Qualcomm (QCOM)	1999-2002	455.18%
Logitech International (LOGI)	1999-2002	408.53%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2002	371.71%
Pool (POOL)	1999-2002	334.37%
CACI International (CACI)	1999-2002	323.97%
Biogen (BIIB)	1999-2002	322.88%
Harmony Gold Mining (HMY)	1999-2002	316.38%
Ryanair Holdings PLC ADR (RYAAY)	1999-2002	309.52%
Infosys Ltd ADR (INFY)	1999-2002	302.54%
Coherent (COHR)	1999-2002	301.5%
Gold Fields Ltd ADR (GFI)	1999-2002	288.77%
Brown & Brown (BRO)	1999-2002	283.96%
UnitedHealth (UNH)	1999-2002	282.49%
Teva Pharma Industries Ltd ADR (TEVA)	1999-2002	278.66%
Genesis Healthcare (GEN)	1999-2002	276.84%
East West Bancorp (EWBC)	1999-2002	273.17%
Agnico Eagle Mines (AEM)	1999-2002	270.03%
Renaissancere (RNR)	1999-2002	261.74%

Large-cap stocks are treated as having a market cap of $10B+.