NVIDIA (NVDA) had the highest return between 2016 and 2024 by a large-cap US stock, returning 16,944.7%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2016-2024	16,944.66%
Advanced Micro Devices (AMD)	2016-2024	4,260.65%
Leonardo DRS, Inc Common Stock (DRS)	2016-2024	4,151.2%
Trade Desk (TTD)	2016-2024	3,988%
Celsius (CELH)	2016-2024	3,972.99%
Axon Enterprise (AXON)	2016-2024	3,396%
argenx NV ADR (ARGX)	2016-2024	3,335.75%
Texas Pacific Land Trust (TPL)	2016-2024	2,875.7%
Sterling Construction (STRL)	2016-2024	2,804.31%
Fortress Transp & Infra Inv (FTAI)	2016-2024	2,736.81%
Kinsale Capital (KNSL)	2016-2024	2,560.75%
Deckers Outdoor (DECK)	2016-2024	2,546.12%
Tesla (TSLA)	2016-2024	2,525.53%
Arista Networks (ANET)	2016-2024	2,171.66%
Fair Isaac (FICO)	2016-2024	2,035.06%
Broadcom (AVGO)	2016-2024	1,986.02%
Ares Management (ARES)	2016-2024	1,943.48%
Apollo Global Management LLC Class A (APO)	2016-2024	1,569.26%
MicroStrategy (MSTR)	2016-2024	1,543.98%
Comfort Systems USA (FIX)	2016-2024	1,513.01%
Quanta Services (PWR)	2016-2024	1,511.08%
Natera (NTRA)	2016-2024	1,473.56%
Fortinet (FTNT)	2016-2024	1,446.82%
MercadoLibre (MELI)	2016-2024	1,423.35%
Carvana (CVNA)	2016-2024	1,406.37%

Large-cap stocks are treated as having a market cap of $10B+.