QXO (QXO) had the highest return between 2010 and 2012 by a large-cap US stock, returning 4,032,075%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2012	4,032,075%
Ferguson (FERG)	2010-2012	228,186.81%
Cheniere Energy (LNG)	2010-2012	651.2%
Regeneron Pharmaceuticals (REGN)	2010-2012	605.73%
Expedia (EXPE)	2010-2012	506.19%
Domino's Pizza Inc Common Stock (DPZ)	2010-2012	451.67%
Ulta Beauty (ULTA)	2010-2012	416.69%
Lululemon Athletica (LULU)	2010-2012	393.88%
United Rentals (URI)	2010-2012	358.87%
Tractor Supply (TSCO)	2010-2012	240%
XPO Logistics (XPO)	2010-2012	234.16%
Chipotle Mexican Grill (CMG)	2010-2012	231.99%
LyondellBasell Industries (LYB)	2010-2012	231.79%
Las Vegas Sands (LVS)	2010-2012	221.6%
Lennar (LEN.B)	2010-2012	217.21%
Transdigm (TDG)	2010-2012	210.18%
Lennar (LEN)	2010-2012	209.36%
EXACT Sciences (EXAS)	2010-2012	202.57%
Booking (BKNG)	2010-2012	179.05%
Ecopetrol SA ADR (EC)	2010-2012	176.36%
Monster Beverage (MNST)	2010-2012	173.36%
Biogen (BIIB)	2010-2012	171.21%
Neurocrine Biosciences (NBIX)	2010-2012	170.04%
Ambev SA ADR (ABEV)	2010-2012	168.43%
Novo Nordisk A-S (NVO)	2010-2012	163.19%

Large-cap stocks are treated as having a market cap of $10B+.