Teck Resources Ltd Class B (TECK) had the highest return between 2016 and 2016 by a large-cap US stock, returning 450.1%.

ASSET	YEARS	% RETURN
Teck Resources Ltd Class B (TECK)	2016-2016	450.06%
Centrais Electricas Brasileiras (EBR)	2016-2016	423.79%
AXIA Energia (AXIA)	2016-2016	423.69%
Advanced Micro Devices (AMD)	2016-2016	309.39%
Coeur Mining (CDE)	2016-2016	248.28%
NVIDIA (NVDA)	2016-2016	233.76%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	2016-2016	222.96%
Hecla Mining (HL)	2016-2016	172.39%
Exelixis (EXEL)	2016-2016	171.09%
SPX (SPXC)	2016-2016	157.27%
ONEOK (OKE)	2016-2016	149.62%
Banco Santander Brasil SA ADR (BSBR)	2016-2016	149.2%
Vale SA ADR (VALE)	2016-2016	141.83%
Targa Resources (TRGP)	2016-2016	137.13%
ArcelorMittal SA ADR (MT)	2016-2016	136.49%
Texas Pacific Land Trust (TPL)	2016-2016	136.02%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2016-2016	134.02%
Pan American Silver (PAAS)	2016-2016	126.75%
MasTec (MTZ)	2016-2016	123.03%
Banco Bradesco SA ADR (BBD)	2016-2016	116.69%
Harmony Gold Mining (HMY)	2016-2016	112.71%
Steel Dynamics (STLD)	2016-2016	106.35%
Alamos Gold (AGI)	2016-2016	104.18%
Burlington Stores (BURL)	2016-2016	102.56%
Freeport-McMoran Copper & Gold (FCX)	2016-2016	99.85%

Large-cap stocks are treated as having a market cap of $10B+.