InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2003 and 2005 by a large-cap US stock, returning 9,214,600%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2003-2005	9,214,600%
Hudbay Minerals (HBM)	2003-2005	6,182.83%
Expedia (EXPE)	2003-2005	5,826.94%
Cheniere Energy (LNG)	2003-2005	5,626.01%
Monster Beverage (MNST)	2003-2005	3,640.09%
Axon Enterprise (AXON)	2003-2005	1,962.22%
Williams Companies (WMB)	2003-2005	1,531.87%
Banco Bradesco SA ADR (BBD)	2003-2005	1,348.11%
Grupo Cibest (CIB)	2003-2005	1,334.13%
ArcelorMittal SA ADR (MT)	2003-2005	1,110.56%
Akamai Technologies (AKAM)	2003-2005	1,007.22%
Apple (AAPL)	2003-2005	901.39%
Paramount Skydance Corporation Class B Common Stock (PSKY)	2003-2005	897.52%
Sterling Construction (STRL)	2003-2005	861.71%
Intuitive Surgical (ISRG)	2003-2005	853.46%
Chunghwa Telecom (CHT)	2003-2005	786.56%
CME (CME)	2003-2005	763.31%
Deckers Outdoor (DECK)	2003-2005	734.37%
Cameco (CCJ)	2003-2005	716.27%
WESCO International (WCC)	2003-2005	664.41%
Teck Resources Ltd Class B (TECK)	2003-2005	660.5%
Alamos Gold (AGI)	2003-2005	607.69%
Canadian Natural Resources (CNQ)	2003-2005	590.52%
Vale SA ADR (VALE)	2003-2005	572.73%
Tenaris SA ADR (TS)	2003-2005	565.34%

Large-cap stocks are treated as having a market cap of $10B+.