Ferguson (FERG) had the highest return between 2010 and 2014 by a large-cap US stock, returning 32,526.5%.

ASSET	YEARS	% RETURN
Ferguson (FERG)	2010-2014	32,526.53%
Cheniere Energy (LNG)	2010-2014	2,716.11%
Regeneron Pharmaceuticals (REGN)	2010-2014	1,592.45%
Domino's Pizza Inc Common Stock (DPZ)	2010-2014	1,124.21%
Tesla (TSLA)	2010-2014	1,070.55%
United Rentals (URI)	2010-2014	928.33%
Neurocrine Biosciences (NBIX)	2010-2014	706.5%
Incyte (INCY)	2010-2014	692.95%
XPO Logistics (XPO)	2010-2014	686%
Chipotle Mexican Grill (CMG)	2010-2014	663.96%
Ulta Beauty (ULTA)	2010-2014	572.23%
DexCom (DXCM)	2010-2014	570.52%
Manhattan Associates (MANH)	2010-2014	569.46%
Biogen (BIIB)	2010-2014	528.96%
Tractor Supply (TSCO)	2010-2014	522.22%
Netflix (NFLX)	2010-2014	515.29%
Constellation Brands Inc Class A (STZ)	2010-2014	512.8%
U-Haul (UHAL)	2010-2014	496.49%
Corpay (CPAY)	2010-2014	494.84%
Axon Enterprise (AXON)	2010-2014	493.72%
Transdigm (TDG)	2010-2014	493.42%
Illumina (ILMN)	2010-2014	493.12%
Broadcom (AVGO)	2010-2014	489.36%
NXP Semiconductors (NXPI)	2010-2014	487.69%
Old Dominion Freight Line (ODFL)	2010-2014	469.03%

Large-cap stocks are treated as having a market cap of $10B+.