NVIDIA (NVDA) had the highest return between 2021 and 2023 by a US stock with a market cap of $100B+, returning 278.8%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2021-2023	278.76%
Eli Lilly and (LLY)	2021-2023	258.34%
Arista Networks (ANET)	2021-2023	223.99%
ConocoPhillips (COP)	2021-2023	222.39%
Constellation Energy (CEG)	2021-2023	214.17%
Novo Nordisk A-S (NVO)	2021-2023	204.71%
Broadcom (AVGO)	2021-2023	176.16%
Exxon Mobil (XOM)	2021-2023	175.35%
Palo Alto Networks (PANW)	2021-2023	148.93%
UBS (UBS)	2021-2023	131.03%
KLA-Tencor (KLAC)	2021-2023	130.11%
Blackstone (BX)	2021-2023	126.4%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2021-2023	118.09%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	2021-2023	115.89%
Dell Technologies (DELL)	2021-2023	115.59%
Eaton (ETN)	2021-2023	112.44%
KKR (KKR)	2021-2023	111.14%
Shell PLC ADR (SHEL)	2021-2023	103.53%
Chevron (CVX)	2021-2023	98.5%
Applied Materials (AMAT)	2021-2023	90.58%
GE Aerospace (GE)	2021-2023	89.64%
TotalEnergies SE ADR (TTE)	2021-2023	88.04%
Costco Wholesale (COST)	2021-2023	82.81%
HSBC Holdings PLC ADR (HSBC)	2021-2023	80.48%
Sumitomo Mitsui Financial (SMFG)	2021-2023	76.24%