QXO (QXO) had the highest return between 2010 and 2016 by a US stock with a market cap of $1B+, returning 3,450,050%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2016	3,450,050%
Inventrust Properties (IVT)	2010-2016	743,020%
Ferguson (FERG)	2010-2016	544,004.49%
Sandstorm Gold Ltd N (SAND)	2010-2016	416,677.78%
Patrick Industries (PATK)	2010-2016	3,001.77%
Par Pacific (PARR)	2010-2016	2,323.33%
ACADIA Pharmaceuticals (ACAD)	2010-2016	2,084.85%
Domino's Pizza Inc Common Stock (DPZ)	2010-2016	2,016.95%
Travere Therapeutics (TVTX)	2010-2016	2,003.33%
Vipshop (VIPS)	2010-2016	1,734.99%
Nexstar Broadcasting (NXST)	2010-2016	1,571.86%
Cheniere Energy (LNG)	2010-2016	1,557.2%
Netflix (NFLX)	2010-2016	1,460.88%
Regeneron Pharmaceuticals (REGN)	2010-2016	1,414.39%
Neurocrine Biosciences (NBIX)	2010-2016	1,297.11%
Silicon Motion Technology (SIMO)	2010-2016	1,290.19%
Jazz Pharmaceuticals (JAZZ)	2010-2016	1,252.73%
CleanSpark (CLSK)	2010-2016	1,246.17%
Ulta Beauty (ULTA)	2010-2016	1,240.58%
Caesars Entertainment (CZR)	2010-2016	1,203.85%
Cidara Therapeutics (CDTX)	2010-2016	1,200%
Lithia Motors (LAD)	2010-2016	1,168.17%
Western Alliance Bancorporation (WAL)	2010-2016	1,152.21%
MarketAxess (MKTX)	2010-2016	1,079.68%
Expedia (EXPE)	2010-2016	1,057.04%