NVIDIA (NVDA) had the highest return between 2016 and 2017 by a US stock with a market cap of $20B+, returning 507.4%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2016-2017	507.44%
Vale SA ADR (VALE)	2016-2017	305.42%
Advanced Micro Devices (AMD)	2016-2017	271.12%
Texas Pacific Land Trust (TPL)	2016-2017	256.81%
argenx NV ADR (ARGX)	2016-2017	252.74%
STMicroelectronics NV ADR (STM)	2016-2017	249.43%
BeiGene (ONC)	2016-2017	237.31%
Take-Two Interactive Software (TTWO)	2016-2017	222.41%
Arista Networks (ANET)	2016-2017	202.61%
Micron Technology (MU)	2016-2017	197.32%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2016-2017	189.96%
Banco Bradesco SA ADR (BBD)	2016-2017	188.43%
Freeport-McMoran Copper & Gold (FCX)	2016-2017	187.27%
Banco Santander Brasil SA ADR (BSBR)	2016-2017	186.85%
Applied Materials (AMAT)	2016-2017	186.4%
MercadoLibre (MELI)	2016-2017	181.89%
Block (XYZ)	2016-2017	171.92%
ArcelorMittal SA ADR (MT)	2016-2017	165.93%
Apollo Global Management LLC Class A (APO)	2016-2017	157.82%
Marvell Technology (MRVL)	2016-2017	156.22%
NRG Energy (NRG)	2016-2017	153.09%
Caterpillar (CAT)	2016-2017	152.75%
Itau Unibanco Banco (ITUB)	2016-2017	148.27%
ONEOK (OKE)	2016-2017	144.35%
Lam Research (LRCX)	2016-2017	143.25%