Marathon Petroleum (MPC) had the highest return between 2021 and 2023 by a US stock with a market cap of $50B+, returning 288.5%.

ASSET	YEARS	% RETURN
Marathon Petroleum (MPC)	2021-2023	288.51%
NVIDIA (NVDA)	2021-2023	278.76%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2021-2023	263.79%
Eli Lilly and (LLY)	2021-2023	258.34%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2021-2023	247.73%
Arista Networks (ANET)	2021-2023	223.99%
ConocoPhillips (COP)	2021-2023	222.39%
Canadian Natural Resources (CNQ)	2021-2023	220.89%
Constellation Energy (CEG)	2021-2023	214.17%
Quanta Services (PWR)	2021-2023	206.33%
Novo Nordisk A-S (NVO)	2021-2023	204.71%
EOG Resources (EOG)	2021-2023	181.24%
Energy Transfer (ET)	2021-2023	181.17%
Broadcom (AVGO)	2021-2023	176.16%
Exxon Mobil (XOM)	2021-2023	175.35%
McKesson (MCK)	2021-2023	171.26%
Vertiv (VRT)	2021-2023	156.46%
Palo Alto Networks (PANW)	2021-2023	148.93%
United Rentals (URI)	2021-2023	148.52%
UBS (UBS)	2021-2023	131.03%
KLA-Tencor (KLAC)	2021-2023	130.11%
Blackstone (BX)	2021-2023	126.4%
Equinor ASA ADR (EQNR)	2021-2023	118.49%
AutoZone (AZO)	2021-2023	118.46%
CoreSite Realty (COR)	2021-2023	118.2%