NVIDIA (NVDA) had the highest return between 2019 and 2025 by a mega-cap US stock, returning 5,658.2%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2019-2025	5,658.2%
Tesla (TSLA)	2019-2025	2,103.79%
Palantir Technologies (PLTR)	2019-2025	1,677.5%
Broadcom (AVGO)	2019-2025	1,578.57%
KLA (KLAC)	2019-2025	1,428.42%
Lam Research (LRCX)	2019-2025	1,306.44%
Advanced Micro Devices (AMD)	2019-2025	1,089.12%
Eli Lilly and (LLY)	2019-2025	928.83%
Arista Networks (ANET)	2019-2025	922.67%
Taiwan Semiconductor Manufacturing (TSM)	2019-2025	877.92%
Micron Technology (MU)	2019-2025	843.61%
GE Aerospace (GE)	2019-2025	789.41%
Applied Materials (AMAT)	2019-2025	764.42%
ASML Holding NV New York Registry Shares (ASML)	2019-2025	643.73%
Apple (AAPL)	2019-2025	638.38%
Crowdstrike (CRWD)	2019-2025	638.2%
Amphenol (APH)	2019-2025	624.97%
Sandisk (SNDK)	2019-2025	577.07%
Goldman Sachs (GS)	2019-2025	529.61%
Alphabet Inc Class C (GOOG)	2019-2025	522%
Alphabet Inc Class A (GOOGL)	2019-2025	514.03%
Palo Alto Networks (PANW)	2019-2025	497.28%
GE Vernova LLC (GEV)	2019-2025	469.67%
Morgan Stanley (MS)	2019-2025	465.7%
Dell Technologies (DELL)	2019-2025	461.93%

Mega-cap stocks are treated as having a market cap of $200B+.