Netflix (NFLX) had the highest return between 2010 and 2019 by a mega-cap US stock, returning 3,979.8%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2010-2019	3,979.81%
Tesla (TSLA)	2010-2019	2,101.68%
Broadcom (AVGO)	2010-2019	1,979.72%
NVIDIA (NVDA)	2010-2019	1,280.27%
Amazon (AMZN)	2010-2019	1,256.21%
Mastercard (MA)	2010-2019	1,116.91%
Apple (AAPL)	2010-2019	1,006.87%
UnitedHealth (UNH)	2010-2019	988.91%
Home Depot (HD)	2010-2019	849.21%
Visa Inc Class A (V)	2010-2019	818.2%
Salesforce (CRM)	2010-2019	771.95%
ASML Holding NV New York Registry Shares (ASML)	2010-2019	761.44%
Lam Research (LRCX)	2010-2019	707.16%
Thermo Fisher Scientific (TMO)	2010-2019	603.22%
Taiwan Semiconductor Manufacturing (TSM)	2010-2019	582.96%
Microsoft (MSFT)	2010-2019	554.22%
Costco Wholesale (COST)	2010-2019	540.36%
Texas Instruments (TXN)	2010-2019	526.37%
Applied Materials (AMAT)	2010-2019	432.35%
Eli Lilly and (LLY)	2010-2019	421.37%
Amgen (AMGN)	2010-2019	419.62%
Micron Technology (MU)	2010-2019	397.04%
Facebook (META)	2010-2019	388.11%
Advanced Micro Devices (AMD)	2010-2019	368.44%
Alphabet Inc Class C (GOOG)	2010-2019	328.12%

Mega-cap stocks are treated as having a market cap of $200B+.