Sandisk (SNDK) has had the highest return between 2021 and 2026 by a mega-cap US stock, returning 4,142.2%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2021-2026	4,142.24%
NVIDIA (NVDA)	2021-2026	1,635.98%
Dell Technologies (DELL)	2021-2026	1,595.93%
Micron Technology (MU)	2021-2026	1,226.17%
Arista Networks (ANET)	2021-2026	1,060.43%
Broadcom (AVGO)	2021-2026	802.49%
Palantir Technologies (PLTR)	2021-2026	774.11%
GE Vernova LLC (GEV)	2021-2026	770.45%
KLA (KLAC)	2021-2026	668.62%
Eli Lilly and (LLY)	2021-2026	640.76%
Lam Research (LRCX)	2021-2026	585.75%
Palo Alto Networks (PANW)	2021-2026	581.8%
Advanced Micro Devices (AMD)	2021-2026	545.14%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2021-2026	519.92%
Applied Materials (AMAT)	2021-2026	497.65%
GE Aerospace (GE)	2021-2026	484.16%
Marvell Technology (MRVL)	2021-2026	467.91%
Amphenol (APH)	2021-2026	454.32%
Exxon Mobil (XOM)	2021-2026	418.48%
Crowdstrike (CRWD)	2021-2026	401.07%
HSBC Holdings PLC ADR (HSBC)	2021-2026	395.7%
Caterpillar (CAT)	2021-2026	383.41%
Arm Holdings plc American Depositary Shares (ARM)	2021-2026	354.97%
Taiwan Semiconductor Manufacturing (TSM)	2021-2026	334.58%
Alphabet Inc Class A (GOOGL)	2021-2026	304.63%

Mega-cap stocks are treated as having a market cap of $200B+.