Sandisk (SNDK) has had the highest return between 2022 and 2026 by a mega-cap US stock, returning 3,902.7%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2022-2026	3,902.68%
Palantir Technologies (PLTR)	2022-2026	994.61%
Micron Technology (MU)	2022-2026	895.93%
Dell Technologies (DELL)	2022-2026	895.62%
GE Vernova LLC (GEV)	2022-2026	722.4%
NVIDIA (NVDA)	2022-2026	645.42%
Broadcom (AVGO)	2022-2026	464.07%
Arista Networks (ANET)	2022-2026	442.49%
GE Aerospace (GE)	2022-2026	429.99%
Crowdstrike (CRWD)	2022-2026	386.42%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2022-2026	372.29%
Eli Lilly and (LLY)	2022-2026	359.39%
KLA (KLAC)	2022-2026	334.34%
Arm Holdings plc American Depositary Shares (ARM)	2022-2026	324.26%
Lam Research (LRCX)	2022-2026	317.63%
HSBC Holdings PLC ADR (HSBC)	2022-2026	307.94%
Palo Alto Networks (PANW)	2022-2026	302.95%
Advanced Micro Devices (AMD)	2022-2026	293.29%
Amphenol (APH)	2022-2026	293.02%
Caterpillar (CAT)	2022-2026	291.6%
Taiwan Semiconductor Manufacturing (TSM)	2022-2026	271.8%
Exxon Mobil (XOM)	2022-2026	239.93%
Applied Materials (AMAT)	2022-2026	194.63%
Marvell Technology (MRVL)	2022-2026	183.91%
Shell PLC ADR (SHEL)	2022-2026	182.58%

Mega-cap stocks are treated as having a market cap of $200B+.